吴文武， 生物信息学博士、三级教授、博士生导师，长期致力于生物大数据应用研究。主要结合计算机科学、正/反向遗传学、基因组学、转录组学、进化分子生物学、生态学等多学科的技术手段，紧密围绕基因转录调控、物种适应性进化等研究方向。近五年来，以第一或通讯作者（含共同）在Brief Bioinform,Cancer Res,Nature Commun, Stem Cell Reports, Plant Cell, Plant J, Plant Commun, J Integr Plant Biol等国际知名期刊上发表科研论文十余篇。
研究方向
在漫漫历史长河中，地球经历了多次生命大爆发和生命大灭绝。近年来，全球暖化加剧，极端气候频发，有研究指出地球或正处于第六次生物大灭绝前期。本课题组主要研究方向为被子植物在逆境胁迫下（如高温、低温等）的分子适应性进化，基于比较基因组、调控组和转录组等生物大数据，从植物基因组中探寻自然选择痕迹，筛选植物前五次生物大灭绝幸存的关键作用基因，并结合分子实验验证，以研究植物在逆境胁迫下的分子适应性进化过程。
学习与工作经历
2017/01—至今 51吃瓜网教授
2016/05—2017/0151吃瓜网副研究员
2014/11—2016/05 中科院上海植物逆境研究中心副研究员朱健康课题组
2012/10—2014/10 中科院上海生科院营养所博士后冯英课题组
2010/10—2011/09 中科院北京植物研究所联合培养孔宏智课题组
2007/09—2012/09 西北农林科技大学博士研究生陶士珩课题组
教学工作
生物信息学理论与实践、测序原理及其分析
科研项目
1. 2018国家自然科学基金面上项目一项，负责人
2. 2017年浙江省科技厅重大科技专项，主要参与人
3. 2015年国家自然科学基金青年科学基金项目一项，负责人
4.2014年中国博士后科学基金第7批特别资助一项，负责人
5.2013年中国博士后科学基金第54批面上资助一项，负责人
论文与专著
2018-2022年（第一作者或通讯作者，†第一作者，*通讯作者）
1. Guo L, Wang S, Nie Y, Shen Y, Ye X,Wu W*. Convergent evolution of AP2/ERF III and IX subfamilies recurrently through polyploidization and tandem duplication in eudicot adaptation to paleoenvironmental changes.Plant communications2022.10.1016/j.xplc.2022.100420
2. Nie Y, Guo L, Cui F, Shen Y, Ye X, Deng D, Wang S*, Zhu J*,Wu W*. Innovations and Stepwise Evolution of CBFs/DREB1s and Their Regulatory Networks in Angiosperms.J Integr Plant Biol2022.10.1111/jipb.13357
3. Ye X, Wang S, Zhao X, Gao N, Wang Y, Yang Y, Wu E, Jiang C, Cheng Y,Wu W*, Liu S*. Role of lncRNAs in cis- and trans-regulatory responses to salt inPopulus trichocarpa.Plant J2022, 110(4): 978-993.
4. Cui F†, Li X†,Wu W†, Luo W, Wu Y, Brosche M, Overmyer K. Ectopic expression of BOTRYTIS SUSCEPTIBLE1 reveals its function as a positive regulator of wound-induced cell death and plant susceptibility to Botrytis.Plant Cell2022.10.1093/plcell/koac206
5. Wang S, Shen Y, Guo L, Tan L, Ye X, Yang Y, Zhao X, Nie Y, Deng D, Liu S*,Wu W*. Innovation and Emerging Roles ofPopulus trichocarpaTEOSINTE BRANCHED1/CYCLOIDEA/PROLIFERATING CELL FACTOR Transcription Factors in Abiotic Stresses by Whole-Genome Duplication.Front Plant Sci2022, 13: 850064.
6. Ye X, Zhao X, Sun Y, Zhang M, Feng S, Zhou A,Wu W*, Ma S*, Liu S*. The underlying molecular conservation and diversification of dioecious flower and leaf buds provide insights into the development, dormancy breaking, flowering, and sex association of willows.Plant Physiol Biochem2021, 167: 651-664.
7. Zhao X, Tan L, Wang S, Shen Y, Guo L, Ye X, Liu S, Feng Y*,Wu W*. The SR Splicing Factors: Providing Perspectives on Their Evolution, Expression, Alternative Splicing, and Function inPopulus trichocarpa.Int J Mol Sci2021, 22(21): 11369.
8. Zhang C, Shen L, Yuan W, Liu Y, Guo R, Luo Y, Zhan Z, Xie Z, Wu G,Wu W*, Feng Y*. Loss of SRSF2 triggers hepatic progenitor cell activation and tumor development in mice.Commun Biol2020, 3(1): 210.
9. 杨艳梅,赵喜娟,聂语琪,柳参奎,吴文武*.草本拟南芥和木本毛果杨在冷胁迫下的研究进展.分子植物育种2020, 18(17): 5755-5764.
10. Wu W*†, Zong J†, Wei N, Cheng J, Zhou X, Cheng Y, Chen D, Guo Q, Zhang B, Feng Y*. CASH: a constructing comprehensive splice site method for detecting alternative splicing events.Brief Bioinform2018, 19(5): 905-917.
11. He L†,Wu W†, Zinta G, Yang L, Wang D, Liu R, Zhang H, Zheng Z, Huang H, Zhang Q, Zhu JK. A naturally occurring epiallele associates with leaf senescence and local climate adaptation inArabidopsisaccessions.Nat Commun2018, 9(1): 460.
2017年及以前（第一作者或通讯作者，†第一作者，*通讯作者）
12. Luo C, Cheng Y, Liu Y, Chen L, Liu L, Wei N, Xie Z,Wu W*, Feng Y*. SRSF2 regulates alternative splicing to drive hepatocellular carcinoma development.Cancer Res2017, 77(5): 1168-1178.
13. Cheng J†, Xu Z†,Wu W†, Zhao L, Li X, Liu Y, Tao S. Training set selection for the prediction of essential genes.PLoS One2014, 9(1): e86805.
14. Zhou X†,Wu W†, Li H, Cheng Y, Wei N, Zong J, Feng X, Xie Z, Chen D, Manley JL, Wang H, Feng Y. Transcriptome analysis of alternative splicing events regulated by SRSF10 reveals position-dependent splicing modulation.Nucleic Acids Res2014, 42(6): 4019-4030.
15. Cheng J,Wu W†, Zhang Y, Li X, Jiang X, Wei G, Tao S. A new computational strategy for predicting essential genes.BMC Genomics2013, 14: 910.
16. Wu W, Huang X, Cheng J, Li Z, de Folter S, Huang Z, Jiang X, Pang H, Tao S. Conservation and Evolution in and among SRF- and MEF2-Type MADS Domains and Their Binding Sites.Mol Biol Evol2011, 28(1): 501-511.
17. Wu W, de Folter S, Shen X, Zhang W, Tao S. Vertebrate Paralogous MEF2 Genes: Origin, Conservation, and Evolution.PLoS One2011, 6(3): e17334.
18. Wu W, Shen X, Tao S. Characteristics of the CArG-SRF binding context in mammalian genomes.Mamm Genome2010, 21(1): 104-113.
其他作者论文
1. Cui X, Gao K, Wang L, Lv M, Li Z, Zheng D,Wu W, Yao W, Ding L, Li X, Others. General Control Non-derepressible 1 (AtGCN1) Is Important for Flowering Time, Plant Growth, Seed Development, and the Transcription/Translation of Specific Genes in Arabidopsis.Front Plant Sci2021, 12: 239.
2. Zhong Y, Xie J, Wen S,Wu W, Tan L, Lei M, Shi H, Zhu J. TPST is involved in fructose regulation of primary root growth in Arabidopsis thaliana.Plant Mol Biol2020, 103(4): 511-525.
3. Yu H, Kong X, Huang H,Wu W, Park J, Yun D, Lee B, Shi H, Zhu J. STCH4/REIL2 confers cold stress tolerance in Arabidopsis by promoting rRNA processing and CBF protein translation.Cell Rep2020, 30(1): 229-242.
4. Cui F,Wu W, Wang K, Zhang Y, Hu Z, Brosch E M, Liu S, Overmyer K. Cell death regulation but not abscisic acid signaling is required for enhanced immunity to Botrytis in Arabidopsis cuticle-permeable mutants.J Exp Bot2019, 70(20): 5971-5984.
5. Wang Q, Wang Y, Liu Y, Zhang C, Luo Y, Guo R, Zhan Z, Wei N, Xie Z, Shen L, Others. U2-related proteins CHERP and SR140 contribute to colorectal tumorigenesis via alternative splicing regulation.Int J Cancer2019, 145(10): 2728-2739.
6. Ye X, Wang H, Cao X, Jin X, Cui F, Bu Y, Liu H,Wu W, Takano T, Liu S. Transcriptome profiling of Puccinellia tenuiflora during seed germination under a long-term saline-alkali stress.Bmc Genomics2019, 20(1): 1-17.
7. Liu L, Luo C, Luo Y, Chen L, Liu Y, Wang Y, Han J, Zhang Y, Wei N, Xie Z,Wu W, Wu G, Feng Y. MRPL33 and its splicing regulator hnRNPK are required for mitochondria function and implicated in tumor progression.Oncogene2018, 37(1): 86-94.
8. Wang L, Li H, Zhao C, Li S, Kong L,Wu W, Kong W, Liu Y, Wei Y, Zhu JK, Zhang H. The inhibition of protein translation mediated by AtGCN1 is essential for cold tolerance in Arabidopsis thaliana.Plant Cell Environ2017, 40(1): 56-68.
9. Yang R, Zheng Z, Chen Q, Yang L, Huang H, Miki D,Wu W, Zeng L, Liu J, Zhou JX, Ogas J, Zhu JK, He XJ, Zhang H. The developmental regulator PKL is required to maintain correct DNA methylation patterns at RNA-directed DNA methylation loci.Genome Biol2017, 18(1): 103.
10. Cao MJ, Zhang YL, Liu X, Huang H, Zhou XE, Wang WL, Zeng A, Zhao CZ, Si T, Du J,Wu W, Wang FX, Xu HE, Zhu JK. Combining chemical and genetic approaches to increase drought resistance in plants.Nat Commun2017, 8(1): 1183.
11. Chen L, Luo C, Shen L, Liu Y, Wang Q, Zhang C, Guo R, Zhang Y, Xie Z, Wei N, Others. SRSF1 prevents DNA damage and promotes tumorigenesis through regulation of DBF4B pre-mRNA splicing.Cell Rep2017, 21(12): 3406-3413.
12. Cheng Y, Luo C,Wu W, Xie Z, Fu X, Feng Y. Liver-Specific Deletion of SRSF2 Caused Acute Liver Failure and Early Death in Mice.Mol Cell Biol2016, 36(11): 1628-1638.
13. Zhan X, Qian B, Cao F,Wu W, Yang L, Guan Q, Gu X, Wang P, Okusolubo TA, Dunn SL, Zhu JK, Zhu J. An Arabidopsis PWI and RRM motif-containing protein is critical for pre-mRNA splicing and ABA responses.Nat Commun2015, 6: 8139.
14. Zhou X,Wu W, Wei N, Cheng Y, Xie Z, Feng Y. Genome-wide analysis of SRSF10-regulated alternative splicing by deep sequencing of chicken transcriptome.Genomics Data2014, 2(0): 20-23.
15. Zhou X, Li X, Cheng Y,Wu W, Xie Z, Xi Q, Han J, Wu G, Fang J, Feng Y. BCLAF1 and its splicing regulator SRSF10 regulate the tumorigenic potential of colon cancer cells.Nat Commun2014, 5: 4581.
16. Li H, Cheng Y,Wu W, Liu Y, Wei N, Feng X, Xie Z, Feng Y. SRSF10 Regulates Alternative Splicing and Is Required for Adipocyte Differentiation.Mol Cell Biol2014, 34(12): 2198-2207.
17. Li L, Guo Y,Wu W, Shi Y, Cheng J, Tao S. A comparison and evaluation of five biclustering algorithms by quantifying goodness of biclusters for gene expression data.Biodata Min2012, 5(1): 8.
18. Marsch-Martínez N,Wu W, de Folter S. The MADS symphonies of transcriptional regulation.Front Plant Sci2011, 2: 26.
联系方式
通讯地址：浙江省杭州市临安区武肃街666号智能实验楼S204
邮 编：311300
电 话：0571-63801232
邮 箱：wwwu@zafu.edu.cn
